The world needs a new approach to treating serious pain

Tris is working with urgency to develop a pipeline of differentiated compounds based on ground-breaking advances in the evolution of pain biology modulation. Our lead investigational compound, cebranopadol, is the world’s first dual nociceptin/orphanin FQ peptide (NOP) receptor and µ-opioid peptide (MOP) receptor (dual-NMR) agonist and has the potential to offer gold-standard efficacy with minimized risk of detrimental side effects.

Breaking the mold in pain biology: effective pain management
with a strong safety profile

At Tris, we are pioneering a fundamentally different approach to pain biology modulation: the dual-NMR agonist.

OPIOID THERAPY
DUAL NMR AGONIST
MOA and NOP receptors

Dual-NMR agonist compounds have the potential to deliver gold-standard pain relief with a strong safety profile because they mimic the body’s natural pain-modulation processes. By leveraging the body’s innate coactivation of NOP and MOP, dual-NMR agonists synergize the analgesic and safety characteristics of the NOP receptor with the analgesic advantages of the MOP receptor. Our investigational dual-NMR agonist, cebranopadol, has been well-characterized, studied in approximately 2,000 patients, and is currently undergoing pivotal Phase 3 trials in various pain types.

Symbolic image of support and care

Research into the potential safety advantages of the dual-NMR mechanism is being supported by the NIH through a significant award

Because of cebranopadol’s novel approach to pain modulation, we have generated promising preclinical data for the treatment of addiction. Based on these findings, Tris has been awarded up to $16.6M over five years from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), to evaluate cebranopadol for the treatment of opioid and substance use disorder.

This research is supported by the National Institute on Drug Abuse of the National Institutes of Health under Award Number UG3DA059285. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Our mission is to bring transformative pain management solutions to patients suffering from acute, chronic and neuropathic pain.